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8.000.6089

Automated sample measurement in Karl Fischer titration


Summary

This poster describes a method for automated and precise dosing of liquid samples into the Karl Fischer titration cell using Metrohm Dosino liquid handling technology. First, the titer was automatically determined with ultrapure water. The same dosing procedure proved valuable for the automated water determination in highly viscous water-glycol fluids and low-boiling organic solvents such as n-pentane. Lastly, the method copes with the labor-intensive and human error-prone suitability test stipulated in chapter 2.5.12 in the European Pharmacopoeia.

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Metrohm Nordic AS

Sandviksveien 26
1363 Høvik

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// Tablets, capsules, pharmaceutical powders// Solvents